What the test examines
Your genotype: inherited DNA variants that may influence how certain methylation-related pathways function.
At-home DNA methylation testing in the USA
DNA Methylation Test USA: At-Home MTHFR & Genetic Wellness Testing
Order an at-home DNA methylation test in the USA to explore inherited variants involved in methylation, folate metabolism, the methionine cycle and related genetic wellness pathways.
The DNA Methylation Test is available for customers in supported U.S. locations and analyzes more than 9,000 genetic locations, including MTHFR, COMT and MTR. Your report is designed to help you understand genetic pathway context without presenting inherited variants as a diagnosis.
- At-home oral-swab collection in the USA
- 9,000+ genetic locations analyzed
- Approx. 10-day laboratory turnaround
- Detailed electronic report
At-home collection
Collect your oral-swab sample privately at home.
Broad genetic scope
Review thousands of inherited genetic locations.
Clear interpretation
Understand genes, variants and pathway context.
Wellness information
Not a diagnosis or measurement of current nutrient levels.
Featured genetic wellness tests
Popular At-Home DNA Tests for Customers in the USA
Compare popular at-home genetic tests available to customers in supported U.S. locations, including methylation, biological aging, longevity and vitamin D metabolism. For the broadest methylation-focused analysis, start with the comprehensive DNA Methylation Test.
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Methylation testing explained
What Is a DNA Methylation Test and How Does It Work?
A DNA methylation test examines inherited genetic variants in genes connected with methylation and related biochemical pathways. These pathways include folate metabolism, one-carbon metabolism, the methylation cycle and the methionine cycle.
What the test does not measure
It does not directly measure your current methylation activity, folate, vitamin B12, homocysteine or other nutrient levels.
How to use the information
Use your results as genetic context alongside medical history, lifestyle, symptoms and appropriate laboratory testing when relevant.
Quick answer: A genetic methylation test can help you understand inherited variants in genes involved in methylation-related pathways. It is an informational genetic wellness test, not a diagnostic test and not a measurement of your current nutrient status.
Comprehensive genetic analysis
What Does the DNA Methylation Test Analyze?
The comprehensive genetic methylation test analyzes more than 9,000 genetic locations and includes genes commonly discussed in methylation and one-carbon metabolism.
MTHFR
MTHFR is involved in folate metabolism and is one of the most frequently researched genes in methylation-related genetic testing.
COMT
COMT is involved in the metabolism of catechol compounds and is commonly reviewed within broader genetic pathway analysis.
MTR
MTR participates in the methionine cycle and is part of the connected network of genes involved in one-carbon metabolism.
More than an MTHFR test
Does the DNA Methylation Test Include MTHFR?
Yes. MTHFR is included as part of the broader methylation analysis.
Many basic MTHFR tests focus on one gene or a small number of variants. A broader methylation panel provides additional context by examining multiple genes that participate in connected pathways rather than treating one MTHFR result as a complete explanation of health or nutritional needs.
If your interest is specifically folate-related genetics, compare the Folate Metabolism 1-Gene Test and the Folate Metabolism 2-Gene Test for Homocysteine.
Simple at-home DNA testing
How Does an At-Home DNA Methylation Test Work?
- Order your test online. Choose the DNA Methylation Test or browse all genetic tests.
- Collect your oral-swab sample. Follow the instructions included with your home collection kit.
- Return your sample. Package and send the sample using the return instructions supplied with the kit.
- Laboratory analysis. Your sample is analyzed for genetic variants included in the methylation panel.
- Receive your report. Your completed report is delivered electronically. Laboratory turnaround is approximately 10 days after the sample reaches the laboratory.
For collection help, see the sample collection guide, visit the Support Center or review the methylation test FAQ.
Understand your genetic report
What Can You Learn From a Genetic Methylation Report?
Your report is designed to organize inherited genetic findings into understandable gene and pathway context. It may help you explore variants associated with:
Folate & methionine pathways
Review genes connected with folate metabolism, one-carbon metabolism and the methionine cycle.
Nutrient-processing genetics
Explore inherited variants associated with how certain nutrient-related pathways are genetically influenced.
Broader wellness pathways
Review genetic context related to energy, stress-response, DNA protection and other report categories.
The report provides genetic context, not a medical diagnosis. Genetics is one part of health alongside environment, diet, medications, medical history, lifestyle and laboratory measurements.
Compare methylation tests
How to Choose a DNA Methylation Test
Not every methylation test examines the same genes, variants or report categories. When comparing DNA methylation tests in the USA, consider the quality and usefulness of the entire testing experience.
Check how many genetic locations are analyzed, which genes are included and whether the test covers one gene or a broader pathway panel.
Review the sample type, collection instructions, shipping eligibility, return process and laboratory turnaround time.
Look for clear explanations of genes, variants, pathway context and the limitations of genetic findings.
For a deeper comparison, read our guide to the best methylation test or browse our methylation test comparisons.
United States testing
DNA Methylation Testing Across the United States
Methylation.us provides at-home DNA methylation testing for customers in supported U.S. locations. Your kit is shipped for home collection, allowing you to collect an oral-swab sample without visiting a clinic, then return it for laboratory analysis according to the supplied instructions.
Explore location information for New York, California, Florida and Texas, or review all supported U.S. locations.
Before ordering, review current pricing, U.S. shipping information, collection instructions and privacy information for your location.
Responsible genetic interpretation
What DNA Methylation Results Can — and Cannot — Tell You
High-quality genetic reporting should explain what was tested, distinguish inherited genotype from current health measurements and avoid turning a single variant into a diagnosis.
Inherited genetic context
Variants in genes such as MTHFR, COMT, MTR, MTRR, CBS, BHMT and PEMT may add context to inherited biology.
Not a current nutrient test
The methylation test does not measure current folate, vitamin B12, homocysteine, vitamins, minerals or other laboratory values.
Not a treatment plan
Genetic findings alone should not determine supplements, medications or treatment. Medical decisions should be made with a qualified healthcare professional.
For focused inherited nutrient-metabolism insights, explore the Vitamin D Metabolism Test or Zinc and Iron Metabolism Test.
More genetic wellness tests
Explore Related At-Home Genetic Tests
If your goals extend beyond methylation, compare focused genetic tests covering biological aging, longevity and nutrition-related traits.
Biological Age Test
Explore information related to biological aging and broader healthy-aging interests.
Longevity Test
Explore genetic information connected with healthy-aging and longevity interests.
Diet & Healthy Weight Test
Explore inherited genetic traits related to nutrition, diet and weight-related wellness characteristics.
Methylation education
Learn About Methylation Genes and Pathways
Methylation involves connected biochemical pathways rather than a single gene. Start with our guide to what methylation is and explore the methylation cycle to understand the broader pathway context.
You can also browse our methylation gene guides, explore information about genetic intolerances and sensitivities, or visit the Methylation.us blog for educational resources.
DNA methylation test FAQ
Frequently Asked Questions About DNA Methylation Testing
Clear answers to common questions about at-home methylation testing, MTHFR testing, sample collection, turnaround time and result interpretation.
What is a DNA methylation test?
A DNA methylation test examines inherited genetic variants in genes involved in methylation and related pathways such as folate metabolism, one-carbon metabolism and the methionine cycle.
Can I take a DNA methylation test at home?
Yes. The test uses an oral-swab sample that can be collected at home and returned according to the instructions supplied with your kit.
Does the DNA methylation test include MTHFR?
Yes. MTHFR is included as part of the broader genetic methylation analysis together with additional genes involved in connected pathways.
How many genetic locations are analyzed?
The comprehensive methylation analysis covers more than 9,000 genetic locations, including genes such as MTHFR, COMT and MTR.
How long does a DNA methylation test take?
Laboratory turnaround is approximately 10 days after the sample is received by the laboratory. Shipping and transit times are separate.
Does a DNA methylation test measure current methylation levels?
No. This genetic test examines inherited variants. It does not directly measure your current methylation activity or current vitamin, mineral, folate, vitamin B12 or homocysteine levels.
Can a DNA methylation test diagnose a medical condition?
No. The test provides informational genetic context about inherited variants and is not intended to diagnose disease or replace medical evaluation.
Can my results tell me which supplements to take?
Genetic results alone should not determine supplements, medications or treatment. Nutrient needs and clinical decisions depend on factors beyond genetics.
Important health information:
Genetic methylation testing provides informational context about inherited
genetic variants. It does not diagnose, prevent or treat disease and does
not measure current vitamin, mineral, nutrient, hormone or other laboratory
levels. Genetic findings should be considered together with medical history,
symptoms, medications, lifestyle and appropriate clinical testing. Discuss
medical concerns, laboratory results, supplements, medications or treatment
decisions with a qualified healthcare professional.
At-home DNA methylation test USA
Order Your At-Home DNA Methylation Test in the USA
Explore inherited variants connected with methylation, folate metabolism, MTHFR, COMT, MTR and related pathways with a comprehensive at-home DNA methylation test available in supported U.S. locations.
Review the test details, understand the collection process and choose the option that best matches your goals.
